Changes of Biologic Marker in Neonatal Sepsis: Is it significance?

Abstract

Introduction. Neonatal sepsis is the leading cause of death in newborns. The initial symptoms of sepsis are usually unclear, the clinician often judge these conditions based on risk factor and clinical examination. Blood culture is one of the parameters to be checked but the result takes time. It is also usually come with a positive result of 10 - 60% only. Another biologic marker such as hematologic one is used to evaluate the sepsis because it is considered faster enough. The aim of study is to evaluate the significant changes in biologic marker during neonatal sepsis with positive risk factors. Methods. This was a cross sectional study. All <72 hours old’s neonates with positive risk factors, neonates who admitted in July to September 2015 in the Neonatal Intensive Care Unit (NICU), and clinically suspected of sepsis were included. Laboratory results of each case were recorded. The eight variables of biologic hematologic parameters of the neonates (hemoglobin, leukocytes, platelet counts, IT (immature to total neutrophil) ratio, IM (immature to mature neutrophil) ratio, polymorphonuclear, immature polymorphonuclear, and hematological scoring (HSS)); one variable of C-reactive protein, and one variable culture result were assessed. Each variable will be compared based on culture result using independent T-test of SPSS. Results and Discussion. Thirty-six samples were found which consist of twenty-nine negative and seven positive sample of culture results. All statistical variable’s results weren’t significant (p >0,05). These results showed there is no significant changes to these variables even if there are any risk factors within the neonates. Higher or lower value of these variable did also not prove whether the culture is positive. Conclusion. No significant changes in biologic marker during neonatal sepsis with positive risk factors.