Abstract
A previous experimental study by the present authors revealed that microcirculatory disturbances are produced by locally‐applied female sex hormones in the cheek‐pouch of hamsters. On the basis of this, the present study was designed to elucidate possible aberration in microvascular permeability induced by these female sex hormones. The permeability characteristics of the vascular wall were evaluated after intraveneous injections of a protein‐bound dye ‐ Evan's blue ‐ whose leakage into the perivascular tissue was considered to indicate increased permeability. In addition, endothelial damage was assessed by vascular labelling with a carbon‐ink suspension. Estrogens and progesterone, in contrast to chorionic gonadotropin, were found to provoke endothelial damage and increased vascular permeability. These findings agree with the clinical features of pregnancy gingivitis.
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