Changes in troponin Ic during a reconditioning program to effort

Abstract

Biological signs of muscle intolerance device to the effort characterized by elevated plasma levels of creatine kinase (CK) can meet during a reconditioning program to effort. The objective of this work was to determine if there were signs of myocardial suffering biological assay Troponin Ic (cTnI) specific infarction during a reconditioning program effort among chronic pain patients, free of cardiac pathologies. This is a unicentric prospective study in routine care. In all patients, plasma levels of cTnI in ng/mL and CK IU/mL were assayed at the entrance and at the end of the first week of rehabilitation protocol. The primary endpoint was the presence of a detectable cTnI levels between 0.01 and 0.04 ng/mL before the reconditioning program and at the end of the first week. One hundred and four patients were included: 52 women and 52 men. No patient had a higher plasma level of cTnI strictly to the threshold of 0.04 ng/mL (diagnostic threshold of myocardial necrosis). Before the beginning of the reconditioning program, 17 patients (16%) had a detectable cTnI levels against 24 patients (23.1%) at the end of the first week ( P = 0.0103). Before the reconditioning program, no patient had muscular exercise intolerance against 44 patients (42%) at the end of the first week. All patients with detectable levels of IcT at the end of the first week was elevated CK, 75% had a muscular exercise intolerance ( P = 0.0003). Seven patients (29.2%) with detectable levels of IcT at the end of the first week had a combination of two cardiovascular risk factors ( P = 0.0049). This study shows that there are some changes in cTnI during a reconditioning program to effort. This rise is linked to a biological muscle peripheral intolerance can hypothesize a similar mechanism.