Abstract
Background: Despite updates to practice guidelines regarding monitoring and treatment of hyperbilirubinemia acute bilirubin encephalopathy (ABE) and its consequence, kernicterus spectrum disorder, continues to occur. Total bilirubin (TB) is the standard measure of bilirubin despite free bilirubin (Bf) being the neurotoxic portion. In this study, we investigated whether Bf in the blood follows the same change as TB over the course of an infant’s treatment for hyperbilirubinemia and if either is predictive of clinical outcomes. Objective: Correlate TB and Bf change over time to the …
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