Abstract
The purpose of this study was to test the hypothesis that a generalized increase in tissue cAMP concentrations after an i.v. injection of cholera enterotoxin may play a role in the development of biochemical and pathological changes leading to death. Dutch rabbits were injected i.v. with highly purified cholera enterotoxin at a dose of 100 or 200 μg/kg. When death appeared imminent (20–30 hr after inoculation), rabbits were anesthetized; plasma, urine, and 13 different tissue samples were obtained for cAMP determinations. Enterotoxin (200 μg/kg) produced significant increases in cAMP concentrations in lung, spinal cord, skeletal muscle, renal cortex, renal medulla and liver, whereas a lower dose (100 μg/kg) had no effect on cAMP levels in any tissue. The elevation of cAMP values in selected tissues suggests differences in tissue sensitivity to cholera enterotoxin; the data fail to support in toto the proposed hypothesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
