Changes in the urinary system in children with enterovirus infection

Abstract

A significant increase in the incidence of enterovirus infections (EVI) with the development of multiple organ damage does not exclude the involvement of the urinary system organs in the pathological process. Materials and methods. 151 EVI children (103 cases with enterovirus meningitis (EVM), 48 children with other forms of EVI without damage of central nervous system) aged from 1 to 18 years. The frequency and nature of changes in urinary sediment and kidney function in patients with various EVI forms were studied. A highly sensitive marker of acute kidney injury - KIM-1 was used as a marker along with standard methods (determination of blood creatinine level with calculation of glomerular filtration rate) in 25 EVM patients. Results. Pathological changes in urinary sediment in EVI are registered in 37.75% of cases (27.1-42.72%, depending on the clinical form), more often in preschool children, are represented by unexpressed proteinuria and abacterial leukocyturia, and are of a short-term transient nature. 40% of EVM children patients showed an increase in the KIM-1 level above the standard values. Conclusion. The detection of KIM-1 in the urine of EVM children patients indicates the possible development of acute transient tubulointerstitial renal damage. At risk there are children with cerebrospinal fluid pleocytosis greater than 200×106/L, abacterial leukocyturia, and decreased glomerular filtration rate.