Abstract
A parenchymal brain granuloma is the final consequence of a localized inflammatory reaction against an infectious agent, particularly parasites. In humans, these lesions are frequent causes of epilepsy. We studied the pattern of seizures induced by pentylenetetrazol (PTZ) in cats with a chronic granuloma induced 1 year earlier by injection of silicates into the brain amygdala. Compared with controls, the seizure threshold to myoclonic seizures was significantly decreased in cats with granuloma, while the threshold for tonic-clonic seizures was not altered. Thus, the difference in PTZ doses between the initial and final components of the seizure became significantly enlarged ( P<0.001). Our results indicate that a granulomatous lesion in amygdala facilitates the generation and propagation of myoclonic seizures, whereas other components of PTZ-induced seizures are not affected.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.