Abstract
Animal models of chronic social stress are known to contribute to a great extent to the research of stress-related disorders in humans. Our previous data revealed a generalized activation of T cells and an altered reaction of T cell subtypes not showing a shift towards Th2 responses after 19 days of chronic subordinate colony housing (CSC), a chronic psycho-social stress model in male mice. In this study, we evaluated the time-dependent effects of CSC on the T cell activation status. Our results demonstrated changes in T cell composition concerning CD3, CD8, CD4 as well as Treg, Th1, and Th17 cells. In addition, the activation status of T cells differed during the time of CSC. In conclusion, CSC stress induced distinct changes in the T cell compartment depending on the duration of stress exposure.
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