Changes in the structure of neuronal connections in the visual cortex of cats with experimentally induced bilateral strabismus

Abstract

The spatial distribution of neuronal connections in cortical field 17 was studied in cats with experimentally induced bilateral convergent strabismus on postnatal days 10-14. Horseradish peroxidase was applied microiontophoretically to individual columns of neurons in fields 17 and 18 and retrograde-labeled cells were identified in both hemispheres. Increases and decreases in the extent of intra-hemisphere connections were seen in the mediolateral direction (projections of the horizontal meridian of the visual field). Most columns showed increases in inter-hemisphere connections in this same direction, which may support the more reliable unification of the two visual hemifields. In addition, some columns showed increases in intra-and inter-hemisphere connections in the rostrocaudal direction (projections of the vertical meridian). Thus, bilateral strabismus induced during the critical period of development leads to changes in the structure of both intra-hemisphere and inter-hemisphere connections of individual cortical columns in fields 17 and 18.