CHANGES IN THE SERUM LEVEL OF LEPTIN AND TRANSFORMING GROWTH FACTOR-Β1 IN PATIENTS WITH ARTERIAL HYPERTENSION ON A BACKGROUND OF ABDOMINAL OBESITY.

Abstract

The aim: Study of the levels of leptin and the growth modulator TGF-β1 in the blood serum of patients with hypertension, which occurs on the background of AO and without it. Materials and methods: Carbohydrate metabolism was studied by the enzymatic method, the level of insulin in the blood (by the enzyme immunoassay method), the oral glucose tolerance test and the calculation of the NOMA index. Results: The data obtained in the work indicate a significant role of leptin in the formation of hypertension itself and the development of obesity, carbohydrate and lipid metabolism disorders. The increased level of transforming growth factor-β1 in the blood of such patients can be used as a fairly informative marker of the unfavorable prognosis of these diseases. Conclusions: 1. In the control group, there was a significant increase in the initial values of heart rate, average levels of SBP and DBP, the frequency of hy-percholesterolemia and insulin resistance was established. 2. Significant disorders of lipid and carbohydrate metabolism and leptin synthesis were found in patients with hypertension, which occurs against the background of AO. 3. When analyzing the level of leptin depending on gender, a statistically significant increase in the level of blood leptin was found in the group of women with AH with AO compared to women with AH without AO and the control group. 4. A significant increase in the level of transforming growth factor-β1 in blood serum of patients with hypertension was established.