Abstract
The rhythmoinotropic dependence of the papillary muscles was studied in rats with postinfarction cardiosclerosis after blocking of beta(1)-adrenoreceptors by concor (7 mg/kg daily). The development of postinfarction cardiosclerosis led to a reduction of the postextrasystolic potentiation and of potentiation induced by periods of rest. Preliminary blocking of beta(1)-adrenoreceptors stimulated the postextrasystolic contractions and contractions after periods of rest in the myocardium of rats with postinfarction cardiosclerosis. These results suggest that blocking of beta(1)-adrenoreceptors promotes an improvement of calcium-accumulating function of the cardiomyocyte sarcoplasmatic reticulum in the myocardium of rats with postinfarction cardiosclerosis.
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