Abstract
BackgroundIn recent years, the popularity of LED lighting has rapidly increased, owing to its many advantages, including economic benefits. We examined the change in the quality of drugs during storage under LED and fluorescent lighting and found that some medicines exhibited a different degree of color change depending on the light source. The purpose of this study was to investigate the effects of different plastic storage bags on the color change over time when various medicines were stored under LED and fluorescent lighting conditions.MethodsPhotostability tests were conducted on several types of target drugs. Subsequently, subjective evaluation by ten evaluators and objective evaluation by image analysis software were carried out regarding color change.ResultsA similar change in color tone was observed after all types of illumination. Subjective evaluation by 10 evaluators revealed that “change in color tone” occurred in the order of bulb-color LED lighting < daylight-color LED lighting < fluorescent lighting, regardless of the type of plastic bags. A similar tendency was observed also in objective evaluation. In this study, it was considered that a brown light-shielding plastic bag was more effective than a normal plastic bag for the prevention of the color change of medicines stored under LED lighting.ConclusionsThe above results suggested that the most appropriate combination of plastic bag and light source for medicine storage was a brown light-shielding plastic bag and bulb-color LED lighting.
Highlights
In recent years, the popularity of Light emitting diode (LED) lighting has rapidly increased, owing to its many advantages, including economic benefits
We examined the differences in the degree of the color change of various medicines after exposure to LED and fluorescent lighting
Changes in the quality of medicines under each condition Additional file 1 shows the results of exposing each medicine at 1000 lx for up to 28 days under LED and fluorescent lighting
Summary
The popularity of LED lighting has rapidly increased, owing to its many advantages, including economic benefits. The purpose of this study was to investigate the effects of different plastic storage bags on the color change over time when various medicines were stored under LED and fluorescent lighting conditions. Medicines are affected by external factors, such as temperature, humidity, and light, during storage in medical institutions and patient homes. These cause physical and chemical changes; a change in appearance and a decrease in titer have been reported [1,2,3]. Various additives are likely added in the manufacturing process in order to impart various functions such as light shielding, antistatic and antimicrobial
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