Abstract
To study an effect of neuroactive amino acids derivatives glufimet and mefargin on the psychoemotional state of rats after chronic alcohol intoxication (CAI). The study was carried out on 10-month-old female Wistar rats. CAI was modeled by replacing drinking water with a 10% solution of ethyl alcohol sweetened with sucrose (50 g/l) for 6 months. Animals (age - 16 months) were divided into groups at the end of alcoholization: 1 (n=15) - intact group - rats without CAI; 2 (n=14) - control - females after CAI; 3 (n=11), 4 (n=14), 5 (n=11) and 6 (n=10) - experimental - females after CAI who received the GABA derivative mefargin (25 mg/kg), the glutamic acid derivative glufimet (29 mg/kg) and comparison drugs phenotropil (25 mg/kg) and heptral (100 mg/kg), respectively. Substances were administered to rats after 6 months of alcoholization intraperitoneally once a day for 14 days, the intact and control groups received physiological saline. The psychoemotional state of the animals was studied in the «Open field» test, «Elevated plus maze» test, «Marble burying» test and the Porsolt swim test after the treatment. In animals of the control group, an increase in anxiety was noted, as evidenced by a greater number of boluses in the Open Field test (3.43±0.56 vs. 1.47±0.39) compared to the intact group (p<0.05), short duration of stay in open arms (26.07±3.47 vs. 68.67±10.08) and fewer hangings from them (3.07±0.25 vs. 6.67±0.79) in the «Elevated plus maze» test. Rats after CAI buried more balls (8.79±1.15 versus 2.73±0.71, p<0.05), which indicated that they had compulsive behavior. In addition, females of the control group were observed to be depressed, as evidenced by a long period of immobilization in the Porsolt swim test (2.36±0.41 versus 0.87±0.31, p<0.05). Mefargin, glufimet, phenotropil and heptral restricted anxiety and manifestations of obsessive-compulsive disorder in females subjected to alcoholism (p<0.05). The antidepressant effect was observed in animals treated with phenotropil and heptral after CAI (p<0.05).
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