Abstract
Rats that had been intubated intragastrically with alcohol two or three times daily for 7 days exhibited a withdrawal syndrome after the cessation of treatment. On the day of withdrawal pentylenetetrazole (PTZ) seizure thresholds were significantly reduced while an elevation was observed from 1 day to 4 weeks after withdrawal. In addition, multiple convulsions were noted after exposure to PTZ from 1 to 7 days after withdrawal. The elevation in PTZ thresholds is apparently not related to physical dependence since administering alcohol once daily for 14 days resulted in no overt withdrawal syndrome but still led to a significant increase in the PTZ threshold. Also, a possible acceleration in the rate of metabolism of PTZ as a result of chronic administration of alcohol does not appear to contribute significantly to the elevated PTZ thresholds since this effect was not antagonized by the administration of SKF 525A one hour prior to the determination of PTZ thresholds. The data suggest that there exists a number of changes in the neuro-excitability of alcohol-dependent rats not previously described in experimental animals.
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