Abstract
The metabolic clearance rate of testosterone (MCR T) in the pregnant and non-pregnant guinea-pig was established by a constant infusion method to steady state levels of 3H testosterone (T). Simultaneously, the concentration of endogenous T was determined by radioimmunoassay and the production rate of T (PR T) was calculated from the product of MCR T and endogenous T concentration. Results indicate important alterations in the three parameters between non-pregnant ( MCR T = 64.0 ± 2.6 1 24 h ; T concentration = 51 ± 8 pg/ml; PR T = 3.24 ± 0.13 μg/24 h) and the pregnant guinea-pig. In these animals mean values from day 43 were about 33 1 24 h for MCR T, 378 Pg/ml for T concentrations and 12.5 μg/24 h for PR T. The significance of these results is discussed in relation to the specific binding of testosterone with the progesterone binding globulin during pregnancy in this species.
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