Changes in the liver histomorphology, catalase and glutathione peroxidase activity in the serum and liver homogenate of normal and monosodium glutamate-intoxicated rats co-treated with artemether-lumefantrine

Abstract

Artemether lumefantrine AL an artemisinin based anti malarial and monosodium glutamate MSG a flavor enhancer respectively mediated oxidative stress with potential interactive effects in non malarial infected hosts Thus changes in the liver histomorphology catalase CAT and glutathione peroxidase GPx activity in the serum and liver homogenate of normal and monosodium glutamate intoxicated rats co treated with artemether lumefantrine were investigated Thirty rats randomly sectioned into six n were exposed to feed and water in addition to nothing Group A control therapeutic dose of AL Group B overdose therapeutic dose times of AL Group C MSG at mg kg body weight Group D therapeutic dose of AL plus MSG Group E and overdose of AL plus MSG Group F Rats exposed to MSG either alone or together with overdose of AL had overriding reduction in the serum and liver homogenate CAT and Gpx activities computed Gpx CAT and CAT Gpx ratios and severe histological changes compared to the control and others suggesting significant adverse effect of overdose of AL together with MSG on the rats rsquo liver morphology and in the serum and liver homogenate CAT and GPx activities Thus exposure of normal rats to in particular overdose of AL together with MSG exerted significant adverse influence on the rats rsquo liver by way of compromised liver morphology and antioxidant capacity It was admonished that non malaria parasite infected rats should not be exposed to AL irrespective of dose either alone or together with intoxicating dose of MSG The possible implications of this study in humans evoke further studies hence are recommended