Abstract
A number of clinicopathological observations about optic nerve damage in glaucoma have been made, however, until now the mechanism of the damage is not clear. It needs abundant histological data in every stage, but it is impossible in human. Experimental glaucoma in monkey is not true copy of human, but it can help us to fill up the gap. Recently we succeeded to develope a wedge shaped retinal nerve fiber layer (RNFL) defect with corresponding round notch and general cupping (Iwata et al. 1985). The scanning electron microscopy (SEM) revealed a new characteristic figures of Lamina cribrosa (L.C.), suggesting mechanical compression and strangulation of axons in two different ways for generalized and localized optic nerve damage. In the eye of descending axon degeneration after optic nerve transection in orbita apex the L.C. showed also local specific obliquely compressed disarrangement of L.C. channel under IOP elevation, suggesting primary local high compressibility to elevated IOP.
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