Abstract
Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5–20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease.Methods: Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.Results: This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls.Conclusions: Hemodialysis procedure contributes to inflammation and oxidative stress.
Highlights
Cardiovascular disease (CVD) is extremely prevalent in maintenance hemodialysis (HD) patients and accounts for approximately half of deaths in chronic kidney disease (CKD) [1].The annual mortality in end-stage renal disease (ESRD) patients is about 10- to 20-fold higher than that in the general population [2]
The present study showed a significant elevation of serum Pentraxin3 after a single session of HD, suggesting the role of dialysis perse in the process of inflammation
Serum Pentraxin-3 and hs-C-reactive protein (CRP) levels were corrected for net UF
Summary
The annual mortality in end-stage renal disease (ESRD) patients is about 10- to 20-fold higher than that in the general population [2]. These patients show a high cardiovascular morbidity and mortality that might be induced by inflammation and oxidative stress. Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5–20 times higher than in the general population. The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.
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