Abstract
A microscopical study was made of the changes occurring in the hypophysis at different times after removal of the anterior hypothalamus (including the pre-optic nuclei); numerous larvae of four anuran species were used. Simultaneous assays of the pituitary glands for thyrotropic hormone were made. The removal of the source of neurosecretion caused a great reduction in the pars posterior and median eminence of the neurohypophysis, and a hypertrophy of the pars intermedia and pars anterior of the adenohypophysis. The basophil cells took up large amounts of water into the cytoplasm, their staining properties changed, and their polysaccharide content was reduced; these changes are attributed to the absence of the thyrotropic effect.
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