Abstract
Induction of Epstein-Barr virus (EBV) in the human lymphoma lines P 3HR-1, and Daudi by TPA (phorbol-12-myristate-13-acetate), n-butyrate, and superinfection with P 3HR-1 virus is associated with an increase in the number of cells bearing Fc receptor (Fc-R). The number of Fc-R per cell, as measured by flow cytometry, is also increased in both cell lines after effective induction of EBV antigens. The increase in cells bearing Fc-R correlates with increased expression of the membrane antigen complex (MA). A high proportion of induced cells concomitantly express both Fc-R and MA in double fluorescence studies. Fc-R activity was not induced by these treatments in EBV-negative lines. After induction of B-95-8 cells (an EBV-transformed marmoset cell line), there is an increase both in MA and whole virus production; however, no Fc-R activity has been detected, suggesting that the B-95-8 EBV strain is incapable of inducing an Fc-R at the cell surface.
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