CHANGES IN THE ENDOMETRIUM AFTER FEMALE SEX ENDOCRINE THERAPY: A CONSIDERATION OF THE EFFECT OF ANTUITRIN-S IN HUMAN SUBJECTS*

Abstract

I wish to present a few clinical facts which suggest the soundness of Novak’s theory that there is a bleeding factor in humans, and which also suggest that at least the immediate relief of dysfunctional uterine bleeding by pregnancy urine extract or P. U. is not attributable to any luteinizing effect on the ovarian follicles. Because of the expense and the inconvenience of extracting hormones from blood and urine, and because of the inaccuracy of the biological tests of these extracts as exact indicators of ovarian activity we have sought more nearly to estimate the degree of follicular activity by study of the endometrium. Here we have a tissue the cytological morphology of which, as far as we know, is entirely under the control of the specific hormones from the follicle and the corpus luteum. We have used a modification of the Klingler-Burch suction curette to obtain fragments of the endometrium from various parts of the inner uterine wall. Studies of such endometrial specimens incident to our attempts ...