Changes in the Dose-Response Relationship of One Toxicant Under Simultaneous Exposure to Another Toxicant.

Abstract

We considered, in general form for a 22 full factorial experiment, linear approximations of the organism’s dose–response relationship for some factors operating alone and modification of this relationship by another factor operating in the background. A typological classification of such modifications is suggested. An analysis of the outcomes obtained in a number of subchronic animal experiments on rats in which this response was assessed by changes in a large number of biomedical indices revealed that all theoretically possible variants (types) of the modification under consideration are actually observed depending on a specific index and specific harmful exposure. Statistical significance estimation procedures are formulated for each of them.