Abstract
THE effects of estrogen and progesterone on uterine composition have been under investigation for some time (for review and discussion see Reynolds, 1). Whereas relaxin has been shown to inhibit uterine motility in vivo and in vitro (2, 3), to modify the histology and increase dilatability of the uterine cervix (4, 5) and very recently, to increase uterine water content (6), its effects on other aspects of uterine physiology and biochemistry have not been elucidated. The present report concerns the effects of a single low dose of relaxin on uterine glycogen, water and nitrogen in the estrogen primed spayed rat. White rats of an inbred commercial strain (Budd Mountain) were used in all experiments. The rats were spayed when 30–32 days old and estrogen primed two weeks later. A small priming dose of estrogen was found to be necessary for marked relaxin effects.
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