Abstract
Studies of the effects of neurotransmitter amino acids on the motor activity of the ciliary apparatus of ependymal cells of the midbrain cerebral aqueduct in neonatal white mice showed that addition of glutamate, GABA-aminobutyric acid, glycine, and taurine to the culture medium induced slowing and then complete cessation of the activity of the ciliary apparatus. Inhibition and cessation of the activity of cilia in response to neurotransmitters, especially glutamate at high concentrations, demonstrated the existence of the corresponding receptors on the membranes of ependymal cells in the cerebral aqueduct, and this was supported by experiments with prior addition of ion channel blockers to the growth medium, i.e., ketamine, strychnine, and bicuculline, which weakened the destructive influences of neurotransmitters and increased the duration of functioning of the ciliary apparatus.
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