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Abstract
We studied the effects of experimental hemic hypoxia of medium severity on the activity of lysosomal cathepsin B in different brain structures of the mother rats and their offspring. Hypoxia was evoked by daily i.p. injections of 60 μg/kg sodium nitrite into pregnant rat females (from the 5th to the 19th day of pregnancy). It resulted in noticeable changes in the activity of cathepsin B in the neocortex, cerebellum, midbrain, and pons Varolii of the “hypoxic” mother rats and their offspring. These changes differed in both the trend and the degree of expression depending on the duration of the post-hypoxic period.
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