Abstract
Changes in testicular LH and FSH receptor numbers were studied in lambs from 10–120 days of age and in 2-yr-old rams. Testicular testosterone and 17β-estradiol were also measured, and a histological examination of testicular parameters was performed in 20-day-old and 2-yr-old animals. The binding affinities of testicular LH receptors (1.4 ± 0.1 × 1010 M-1) and FSH receptors (3.7 ± 0.2 109 M-1) did not differ with age. The concentration of LH receptors (expressed per milligram of membrane protein) decreased from 31 to 6 fmol between 10– 120 days of age, but that of FSH receptors increased from 65 to 95 fmol. The total number of LH receptors per testis increased from 0.06 to 0.6 pmol between 10–80 days of age, then to 2.0 pmol by 120 days of age. The total number of LH receptors per testis did not differ between 120-day-old and 2-yr-old rams, but this was the result of a concomitant increase in the number of Leydig cells and a decrease in the number of LH receptors per Leydig cell. The change in the total n...
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