Abstract
Investigators at University Hospital, Heidelberg, and other centers in Germany, studied the composition of the peripheral T-cell compartment and regulatory T cell (Treg) function in 30 pediatric MS patients by multicolor flow cytometry and proliferation assays.
Highlights
Homeostatic changes in circulating T cells paralleled the pattern in adult MS
Signs of early thymic involution are found in pediatric MS, suggesting that an intrinsic compromise in thymic-dependent T-cell neogenesis might contribute to MS pathogenesis
The authors conclude that the similarities in the T-cell compartment between adult and pediatric MS patients support a shared disease pathogenesis, immunologic disease mechanism, and response to therapy
Summary
Neurobiological abnormalities in infants who later develop ASD. Studies since 2009 showing abnormalities in head circumference, electrophysiological markers and interhemispheric synchronization and differences in various brain regions (amygdala, cerebellum, frontal and temporal cortex) are reviewed by investigators at the University of Glasgow, Scotland. Cross-disciplinary approaches are essential to elucidate sequence of developmental abnormalities during early infancy leading to ASD Eyeblink conditioning (EBC) is proposed as a non-invasive biomarker for ASD that can be employed shortly after birth
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