Changes in systemic redistribution of blood flow by vasodilators.

Abstract

For the last 20 years, vasodilator drugs have been used for the therapy of congestive heart failure. During this period, there has been increasing interest in the treatment of congestive heart failure. Vasodilators are divided into one which reduces preload, another which reduces after-load and the last which has both effects. Changes in cardiac output causes changes in distribution of cardiac output to each organ. Therefore, after vasodilators injection, changes in systemic distribution of blood flow should not be equal in each organ. In this report, changes in systemic distribution of cardiac output after vasodilator injection are discussed. Systemic distribution of blood flow in normal circulation differs from that in abnormal circulation. In this report, effects of vasodilators on systemic distribution of cardiac output in the state of experimentally created heart failure are discussed.