Abstract
Introduction: This study aimed to evaluate the changes both in the systemic inflammation and in the mucociliary clearance following smoking cessation, and their associations with smoking characteristics.Methods: A total of 30 cases admitted to Konya Training and Research Hospital, University of Health Sciences, Department of Smoking Cessation were recruited, and 27 of them completed the study. Tumor necrosis factor alpha (TNF-α), interleukin (IL) -4, IL-6, IL-8, IL-10 and saccharin transit time (STT) was measuredat the beginning and 2 months after smoking cessation.Results: We found in this study that STT decreased significantly in 2 months after cessation (p<0.001). In our study, we found that serum TNF-α (p=0.035) and IL-8 (p=0.002) levels were decreased significantly at 2 months after quitting when compared with the basal levels. In our study, serum IL-6 (p=0.132) and IL-10 (p=0.657) levels did not change significantly in the 2nd month of quitting, when compared to basal levels.Conclusion: In this study, two months after smoking cessation, nasal mucosal clearance and systemic inflammatory response especially plasma TNF- α and IL-8 levels were improved. We think that further studies with larger sample size and longer follow-up will provide more detailed data about the improvements in systemic inflammation.
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