Abstract
The effect of hydrogen peroxide (H 2O 2) on excitatory and inhibitory synaptic transmission was studied at the lobster neuromuscular junction. H 2O 2 produced a dose dependent decrease in the amplitude of the junction potential ( V ejp ). This decrease was due to changes in both presynaptic transmitter release and the postsynaptic response to the neurotransmitter. Observed presynaptic changes due to exposure to H 2O 2 were a decrease in the amount of transmitter released, that is, quantal content, as well as a decrease in the fast facilitation, that is, the amplitude increase of successive excitatory junction potentials at a rate of 3 Hz. To discern postsynaptic changes, glutamate, the putative excitatory neurotransmitter for this preparation was applied directly to the bathing medium in order to bypass the presynaptic release process. H 2O 2 produced a decreased response of the glutamate receptor/ ionophore. The action of H 2O 2 was not selective to excitatory (glutamate-mediated) transmission because inhibitory (GABA-mediated) transmission was also depressed by H 2O 2. This effect was primarily presynaptic since H 2O 2 produced no change in the postsynaptic response to applied GABA.
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