Abstract
Specific binding of 3H-atropine to crude synaptosomal membrane fractions of the rat striatum was measured at different times after unilateral 6-hydroxydopamine lesions of the nigrostriatal dopaminergic neurones. In a group of rats killed between 4 to 15 days after lesioning the right side, specific 3H-atropine binding was reduced by 20 percent compared to the right side of unlesioned rats. There was a concomitant increase (20 percent) of specific 3H-atropine binding in the contralateral side compared to control animals. These changes in muscarinic receptor binding depended on the time after which the lesions were made : maximum effects occured about 8 days after lesioning but almost completely disappeared 13 days later. Dissociation constants for 3H-atropine in the right and left striata of control and lesioned rats were not significantly different. The decrease in muscarinic receptor binding in the ipsilateral striatum of lesioned animals may result from an activation of cholinergic neurones produced by removal of the inhibitory dopaminergic terminals.
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