Abstract
Purpose: Osteoarthritis (OA) is a disease affecting all joint tissues. The ability to identify OA early, prevent the initial cartilage breakdown and stimulate repair would provide an effective strategy for both its prevention and treatment. Synovial fluid (SF) represents a potential source of disease-specific small non-coding RNAs (sncRNAs) that could be used as biomarkers and aid in the understanding of the pathogenesis of OA. SncRNAs are short, typically less than 200 base pairs (bp), RNA species, which are not translated into protein but have other structural or regulatory roles.
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