Abstract
Objective: This study aimed to determine whether changes in sleep duration are associated with a higher risk of mild cognitive impairment (MCI) in older adults.Results: By the 3-year follow-up, 592 participants developed MCI. Compared with the individuals who had an unchanged sleep duration, the odds ratio (95% confidence interval) for MCI was 1.44 (1.08-1.91) for those whose sleep duration increased by ≥2 h after multivariate adjustments. Moreover, changing from a long to moderate, but not short, sleep duration was negatively associated with the incidence of MCI (odds ratio: 0.65; 95% confidence interval, 0.45-0.93).Conclusions: These findings suggest that increased sleep duration is associated with a higher risk of MCI in the elderly. Furthermore, a moderate duration of sleep (6-9 h) could serve as a possible strategy for prevention of MCI.Methods: This longitudinal study was conducted with a nationally representative sample of 5419 older Chinese adults (≥65 years) from the 2008 and 2011 waves of the Chinese Longitudinal Healthy Longevity Survey. Sleep duration was assessed by a self-administered questionnaire. MCI was defined according to the Mini-Mental State Examination. An adjusted logistic regression model was used to explore the associations between changes in sleep duration and MCI.
Highlights
Mild cognitive impairment (MCI) has been defined as an intermediate stage between normal aging and dementia that is characterized by cognitive deficits [1]
Based on data from two waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) occurring from 2008 to 2011, this study aimed to evaluate whether changes in sleep duration over a 3year period were associated with the subsequent risk of MCI and to consider several potential confounding factors among older adults from China
The results of this study indicated that an increase in sleep duration was significantly associated with a higher risk of developing MCI among older Chinese adults
Summary
Mild cognitive impairment (MCI) has been defined as an intermediate stage between normal aging and dementia that is characterized by cognitive deficits [1]. Older adults commonly experience sleep problems, and abnormal sleep durations have been recognized to impair performance on attention and executive control tasks [6] Poor sleep health, both self-reported long and short sleep durations, has been shown to be associated with cognitive decline in older adults [7,8,9], not consistently. Few studies have focused on the relationship between changes in sleep duration and MCI, which represents early-stage dementia [13]. Another Whitehall II Study [14] found an increase from 7 or 8 h sleep and a decrease from 6 to 8 h of sleep were associated with lower cognitive function in the middleaged individuals. Considering the high prevalence of MCI among the elderly, the associations between changes in sleep duration and the development of MCI in the elderly need to be further investigated
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