Abstract
Blood perfusing isolated dog gracilis muscles was equilibrated with CO 2 tensions ranging from 30 to 120 mm Hg, resulting in venous P CO 2 from 35 to 135 mm Hg. Extracellular pH values ranged from 6.96 to 7.41, and muscle cell pH, calculated from DM0 distribution, ranged from 6.64 to 6.94. When intracellular pH was plotted as a function of the corresponding extracellular pH, a linear relationship (r = O.92) was observed throughout the entire pH range. The slope ΔpH i/ ΔpH e was 0.64, without evidence of a difference in slope at different pH values. These results do not support the previous observations in rat diaphragms that cell pH is not affected by P CO 2 changes over a certain extracellular pH range.
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