Abstract
The level of host resistance to Plasmodium chabaudi is genetically determined by a major, dominant, autosomal, non H-2 linked gene which has been designated Pchr (for resistance to P. chabaudi) The genetic control was defined by our laboratory by analysis of hybrid and backcross progeny derived from the strain combination of resistant C57BL/6J (B) and susceptible A/J (A) mice and was confirmed by analysis of the AXB/BXA series of recombinant inbred (RI) strains (1,2). The RI strain analysis showed, furthermore, that resistance and, consequently, survival are genetically linked with marked splenomegaly while susceptibility and death are linked with minimal splenomegaly.
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