Abstract
The effects of cortisol on the spontaneous activity of single cells in the anteriortuberal and posterior hypothalamus and their responsiveness to photic, acoustic and sciatic stimulation were studied in cats under pentobarbital anesthesia. It was found that while before hormone administration the sensory stimuli caused a predominant increase in cell firing in the anterior-tuberal hypothalamus, after the hormone administration the effect was mainly inhibitory. On the other hand, in the posterior hypothalamus the hormone caused a further increase in cell firing following sensory stimulation. These results are discussed in view of the role played by the anteriortuberal hypothalamus in adrenocortical regulation and the negative feedback exerted by the glucocorticoids at hypothalamic levels. It is suggested that the present data may possibly demonstrate some electrophysiological correlates of the neuroendocrine effects of the adrenocortical hormones, exerted on the hypothalamus.
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