Abstract
Changes in Several Disease Parameters Including Abzymes and Hematopoietic Progenitor Colony Formation in Brain Inflammation and Demyelination
Highlights
Multiple sclerosis (MS) is a demyelinating and inflammatory condition of the central nervous system (CNS) associated with perivascular infiltrates composed largely of T lymphocytes and macrophages
The treatment of mice with cuprizone leads to a significant decrease of several indexes characterizing spontaneous and myelin oligodendrocyte glycoprotein (MOG35-55) - induced EAE: increased levels of titers of antiDNA and anti-MOG antibodies, proteinuria, the generation of abzymes hydrolyzing MOG, myelin basic protein (MBP), and DNA
The average mice weight loss was revealed after several days in cuprizone- and MOG-treated comparing with untreated control mice (Figure 1A)
Summary
Multiple sclerosis (MS) is a demyelinating and inflammatory condition of the central nervous system (CNS) associated with perivascular infiltrates composed largely of T lymphocytes and macrophages. Despite the fact that the precise cause of MS remains unknown, numerous research data support the hypothesis of autoimmune mechanisms including the destruction of myelin playing a major role in the development of MS [1]. That activation of CD4+ myelin-reactive T cells may be major mediator of MS. Several recent findings imply B cells important role and autoantibodies (auto-Abs) against autoantigens of myelin in the pathogenesis of MS [1,2,3]. Dual important role of auto-Abs was suggested: they may be potentially beneficial in lesion repair and vice versa be harmful in lesion formation [2]. In the cerebrospinal fluid (CSF) increased level of oligoclonal immunoglobulin G (IgG) and total Abs as well
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