Abstract
Rats trained to bar-press on either a FI 15 sec or FR 30 schedule for water reinforcement were administered various doses of apomorphine, haloperidol, pilocarpine and scopolamine both before and 1–4 months after a 3-day period of continuous morphine administration. All drugs monotonically depressed response rates on both schedules with increasing dose. Chronic morphine administration produced a persistent increase in sensitivity to apomorphine and pilocarpine and a persistent decrease in sensitivity to haloperidol and scopolamine. The results suggest that both dopaminergic and cholinergic supersensitivity are likely to be involved in protracted abstinence phenomena.
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