Abstract
We have previously shown that acute inflammatory response causes robust alterations of state and trait dimensions of self-rated health. Here, we repeat the previous study using a higher dose of endotoxin and investigate consequences of inflammation that may mediate changes in health appraisal. 22 healthy subjects were injected twice, once with endotoxin (lipopolysaccharide 2.0 ng/kg) and once with placebo, with a minimum of 20 days between. Self-rated health, sickness behavior (using the Sickness Questionnaire) and interleukin (IL)-6, IL-8 and TNF-alpha were assessed before, 3 and 7 h after injection. Three hours after injection, current health (“How is your health right now?”) was significantly poorer in the endotoxin group ( b = 2.82, p b = 0.50, p
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