Changes in Sedation Practices in Association with Delirium Screening in Infants After Cardiopulmonary Bypass.

Abstract

Sedation in the cardiac intensive care unit (CICU) is necessary to keep critically ill infants safe and comfortable. However, long-term use of sedatives may be associated with adverse neurodevelopmental outcomes. We aimed to examine sedation practices in the CICU after the implementation of the Cornell Assessment of Pediatric Delirium (CAPD). We hypothesize the use of the CAPD would be associated with a decrease in sedative weans at CICU discharge. This is a single institution, retrospective cohort study. The study inclusion criteria were term infants, birthweight > 2.5kg, cardiopulmonary bypass (CPB), and mechanical ventilation (MV) on postoperative day zero. During the study period, 50 and 35 patients respectively,met criteria pre- and post-implementation of CAPD screening. Our results showed a statistically significant increase in theincidence of sedative habituation wean atCICUdischarge after CAPD implementation (24% vs. 45.7%,p = 0.036). There was a statistically significant increase inexposureto opiate (56% vs. 88.6%, p = 0.001) and dexmedetomidine infusions(52% vs 80%, p = 0.008), increased likelihood of clonidine use at CICU discharge (OR 9.25, CI 2.39-35.84), and increase in the duration of intravenous sedative infusions (8.1days vs. 5.1days, p = 0.04) No statistical difference was found inexposure to fentanyl (42% vs. 58.8%, p = 0.13)ormidazolam infusions(22% vs. 25.7%, p = 0.691); and there was no change inbenzodiazepine or opiate use at CICU discharge or dosage. The prevalence of delirium in the CAPD cohort was 92%. CAPD implementationin the CICU was associated with changes in sedation practices, specifically an increase in the use of dexmedetomidine, which possibly explains the increased clonidine weans at CICU discharge. This is the firstreportof theassociation between CAPD monitoring and changes in sedative practices. Multi-center prospective studies are recommended to evaluate sedative practices, delirium, and its effects on neurodevelopment.