Abstract
Following intra-arterial administration of ethacrynic acid (EA) in the guinea pig (50 mg/kg), the endocochlear potential declines from its normal value of + 80 mV to − 30 to − 40 mV, similar to that during asphyxic anoxia. The regression line describing the change in CM amplitude as a function of EP amplitude is statistically identical for both anoxia and EA administration, with a slope of 0.49 and a correlation coefficient of 0.96. Perfusion of scala vestibuli with isotonic KCl had no significant effect on the value of the negative EP resulting from EA administration. These results suggest that (i) changes in CM amplitude following EA administration are due solely to the depression of the EP resulting from the action of EA on energy production in the stria vascularis, and (ii) the negative EP is not the result of a K+-diffusion gradient across Reissner's membrane. [Supported by grants from the Deafness Research Foundation and USPHS 08193.]
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