Abstract
B. The serum T3/T4 ratio was significantly lower in group A than in group B after 2 and 4 weeks of treatment (2 weeks: A = 2.48 f 0.58, B = 3.36 f 0.69, P < 0.05; 4 weeks: A = 2.18 f 0.58, B = 2.87 f 0.60, P < 0.05). Plasma propranolol levels varied widely at both 7 h (mean 50.6, range 29-67 pg/ml) and 24 h (mean 39.7, range 22-73 pglml). No significant correlation was noted between plasma propranolol and the change in serum T3 ( r = 0.24) and T4 ( r = 0.17). We suggest that LAP is valuable in the treatment of hyperthyroidism and confirm that its action is not solely related to the decrease in serum T3. The rise in serum T4 may be due to LAP inhibiting its metabolism. Caution is advised when interpreting T4 levels in patients receiving LAP.
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