Abstract
Background Changes in CSF circulation, as seen in adult chronic hydrocephalus (CH), can result in changes in CSF content, neurodegeneration, a loss of neurological function, and death. The microtubule-associated protein, Tau has been implicated in the pathogenic mechanisms of dementia and neurodegenerative disorders through accumulation in CSF and brain. To date, the relationship between the CSF circulation changes in CH and the levels of tau in CSF and brain has not been studied.
Highlights
Changes in CSF circulation, as seen in adult chronic hydrocephalus (CH), can result in changes in CSF content, neurodegeneration, a loss of neurological function, and death
This study used an experimental model of chronic obstructive hydrocephalus developed in our laboratory to investigate whether changes in CSF circulation could have an effect on the level of Tau protein in CSF and brain
Our preliminary findings suggest that CSF circulation may play a physiologically significant role in the pathophysiology of Tau protein clearance, and in turn may influence brain parenchymal tau levels
Summary
Address: Section of Pediatric and Congenital Neurosurgery, Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. Cerebrospinal Fluid Research 2004, 1(Suppl 1):S18 doi:10.1186/1743-8454-1-S1-S18. 48th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Meeting abstracts
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