Abstract
The dermal fibroblasts are in constant contact with the cells of the immune system and skin epidermis. Therefore, they are essential for the development of lesions in psoriasis. The aim of this study was to assess the changes in the proteomic profile of fibroblasts in the dermis of psoriasis patients, and to discuss the most significant changes and their potential consequences. The proteomic results indicate that fibroblast dysfunction arises from the upregulation of proinflammatory factors and antioxidant proteins, as well as those involved in signal transduction and participating in proteolytic processes. Moreover, downregulated proteins in psoriatic fibroblasts are mainly responsible for the transcription/translation processes, glycolysis/ adenosine triphosphate synthesis and structural molecules. These changes can directly affect intercellular signaling and promote the hyperproliferation of epidermal cells. A better understanding of the metabolic effects of the proteomic changes observed could guide the development of new pharmacotherapies for psoriasis.
Highlights
Psoriasis is a chronic disease that occurs with increasing frequency in developed countries
The results presented in this study show that the proteome of fibroblasts isolated from the dermis of psoriatic patients has a different profile than that of control cells
The data obtained from our proteomic analysis allowed us to identify and semi-quantitatively determine the expressions of 718 proteins, 684 of which were found in control fibroblasts, and 690 in cells isolated from the skin of
Summary
Psoriasis is a chronic disease that occurs with increasing frequency in developed countries. In European countries and the United States, the prevalence of psoriasis can reach 3% [1,2]. Psoriasis occurs mainly due to a dysfunction of the immune system, and its development might be associated with other diseases, including arthritis, metabolic syndrome, heart disease, polycystic ovarian syndrome, chronic obstructive pulmonary disease and even cancer [3]. The main symptom of the disease is excessive skin exfoliation [4]. Psoriasis affects the psychophysical health of patients by lowering their self-esteem and disrupting their social behavior. Depressive symptoms and sleep disturbances are common in psoriatic patients [5,6]
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