Abstract

Changes in porcine growth, biochemical parameters, histopathology, and melamine residue levels in tissues induced by consumption of melamine and cyanuric acid

Highlights

  • Melamine (C3H6N6; MEL) is a white, crystalline powder [1] with a wide variety of industrial applications including use in manufacturing of plastics, adhesives, laminates, paints, flame retardants, textiles finishes, and fertilizers [2]

  • It has been reported [10,12] that blood urea nitrogen (BUN) levels increase in animals fed MEL and Cyanuric acid (CYA) due to a decrease in kidney function

  • Extra pigs fed the combination of MEL + CYA had an 18-day body weight gain (BWG) of 7.76 kg and an average daily gain (ADG) of 0.43

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Summary

Introduction

Melamine (C3H6N6; MEL) is a white, crystalline powder [1] with a wide variety of industrial applications including use in manufacturing of plastics, adhesives, laminates, paints, flame retardants, textiles finishes, and fertilizers [2]. MEL is 66 % nitrogen [8], protein analysis using the Kjeldahl method will result in an invalid or an over estimate of the actual protein content of a matrix that contains MEL [8] For this reason, MEL was intentionally added to feed ingredients and feeds to increase their monetary value [9]. Precipitation of MEL-CYA crystals in the kidneys of dogs and/or cats has been reported by several authors [911]. It has been reported [10,12] that blood urea nitrogen (BUN) levels increase in animals fed MEL and CYA due to a decrease in kidney function. Possible routes of absorption of MEL and related compounds as well as how precipitation of the compounds can lead to renal damage and renal failure have been previously described [12,13]

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