Abstract
The aim of this study is to discuss the effect of anti-oxidant supplement (Rv-PEM01-99, Kibun Foods, Inc., Tokyo, Japan) on changes in energy metabolism in obese dogs. 200 mg/kg/day of Rv-PEM01-99 (equivalent to 5 mg kg/day of quercetin derivative) were applied for 6 weeks to the Beagle dogs fed high fat diet (HFD) or control diet (CD). In the present study, body weight (BW) decreasing effect of Rv-PEM 01-99 in obese dogs was not clear. However, plasma alkaline phosphatase (ALP) activities at the end of experiment were significantly decreased compared to those at the start of experiment in obese dogs supplemented with Rv-PEM 01-99 (paired-t test, p < 0.05). In control dogs supplemented with Rv-PEM 01-99, Plasma malondialdehyde (MDA), and triglycerides (TG) levels and lactate dehydrogenase (LDH) activities were significantly decreased compared to those at the start of experiment (paired-t test, p < 0.05). From these findings, Rv-PEM 01-99 seems to be not harmful for dogs. Anti-lipid peroxide effect and liver function improvement are expected in the dogs supplemented with Rv-PEM 01-99.
Highlights
Occurrence of obesity and its related metabolic disorders have increased in dogs and cats as in humans [1, 2]
The aim of this study is to discuss the effect of anti-oxidant supplement (Rv-PEM01-99, Kibun Foods, Inc., Tokyo, Japan) on changes in energy metabolism in obese dogs. 200 mg/kg/day of Rv-PEM01-99 were applied for 6 weeks to the Beagle dogs fed high fat diet (HFD) or control diet (CD)
To investigate anti-obesity effect of Rv-PEM 01-99 in dogs, we developed obese dogs by feeding HFD for 6 weeks
Summary
Occurrence of obesity and its related metabolic disorders have increased in dogs and cats as in humans [1, 2]. Obesity accompanied by visceral fat accumulation causes insulin resistance and is a risk factor for metabolic syndrome, diabetes mellitus, hypertension, dyslipidemia, cardiovascular diseases, musculoskeletal disorders, and some forms of cancer [3, 4]. Some of the inflammatory cytokines, such as tumor necrosis factor-α(TNF-α), IL-1β, and IL-6, and C-reactive protein (CRP) are released from adipose tissue in obese animals. Oxidative stress, which results from an imbalance between the amount of pro-oxidants and antioxidants, contributes to a cause of insulin resistance [6]. Leptin (LP) and adiponectin (ADN) are secreted from adipose tissue in obese animals. LP increases serum TNF-α and IL-6 concentrations and induces insulin resistance while ADN has anti-inflammatory properties and decreases the release of proinflammatory mediators [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
