Abstract
The effects of general anaesthesia and operation on plasma levels of oestradiol, oestrone and progesterone have been investigated in 19 pre- and 3 postmenopausal women. Plasma samples were obtained preoperatively, at induction of anaesthesia, 15 min postinduction, during operation and from some subjects at later time intervals. Anaesthesia and operation produced no consistent effect on the concentration of oestradiol, oestrone and progesterone in plasma with increases or decreases in the levels of all three hormones occurring. Changes in the plasma concentrations of oestrone at induction and during operation were less than ± 15% compared with pre-operative levels. Marked changes, however (up to 271%), were seen for oestradiol and progesterone in some, but not all, premenopausal women studied during the proliferative phase and in postmenopausal women, whereas relatively less variation occurred in women studied during the secretory phase. As hormone receptor levels are frequently measured on tissues obtained at operation under general anaesthesia, changes in plasma hormone concentrations, resulting from these procedures, should be considered when investigating hormone receptor distribution within the cell.
Published Version
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