Abstract
The plasma corticosterone levels and incorporation of 14C-l-acetate into corticosterone and cortisol were measured in dehydroepiandrosterone (DHA)-treated persistent estrous rats and control estrous cyclic rats exposed to cold (-5 degrees C) for 12 hrs. Cold exposure significantly facilitated incorporation of 14C-l-acetate into corticosterone and cortisol in both DHA-treated and control rats. However, the rates of increase of plasma corticosterone level and 14C-incorporation into corticosterone are 61% and 77% in controls, and 19% and 44% in DHA-treated rats, respectively. The activity of stress-induced pituitary-adrenal function showed masculine patterns in DHA-treated rats. The diurnal patterns of plasma corticosterone in DHA-treated rats are similar in controls. Plasma corticosterone levels in DHA-treated rats are evidently greater than those in controls. It is suggested that neonatal administration of DHA caused the changes not only in pituitary-gonadal system but also in pituitary-adrenal system.
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