Changes in Physical Activity and Sedentary Patterns on Cardiometabolic Outcomes in the Transition to Adolescence: International Children's Accelerometry Database 2.0

Abstract

To examine the associations of changes in physical activity and sedentary patterns with changes in cardiometabolic outcomes from childhood to adolescence. Youth from the International Children's Accelerometry Database (n=1088; 55% girls), aged 8-13years and followed for ∼4years, were used in this analysis. Hip-mounted accelerometers were used and all physical activity intensities were expressed as the % of total wear-time. Sedentary time was separated into time spent in bouts <10minutes and ≥10minutes. A composite z score for cardiometabolic risk (CMR score) was computed by summing the standardized values for systolic and diastolic blood pressure, triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and the inverse high-density lipoprotein cholesterol. Multivariate analyses were performed using adjusted linear regression models. Increase in sedentary time was unfavorably associated with changes in CMR score (β=0.021; CI 0.004-0.037), TG (β=0.003; CI 0.001-0.005), and diastolic blood pressure (β=0.068; CI 0.009-0.128). Decrease in moderate-to-vigorous physical activity was unfavorably associated with changes in LDL-c (β=-0.009; CI -0.017 to -0.001) and TG (β=-0.007; CI -0.013 to -0.001). Increase in ≥10minutes sedentary time was unfavorably associated with changes in CMR score (β=0.017; CI 0.004-0.030), LDL-c (β=0.003; CI 0.000-0.005), and TG (β=0.003; CI 0.000-0.004). Decrease in light-intensity physical activity was unfavorably associated with changes in CMR score (β=-0.020; CI=-0.040 to 0.000). More physical activity and less prolonged sedentary time are beneficial for cardiometabolic health in youth transitioning to adolescence.