Abstract

The activity of acid and alkaline phosphatases and acid cathepsins in subcellular fractions (especially in the postmitochondrial supernatant) of the gray matter of the dog brain rises proportionally to the duration of compression ischemia. The activity of the last two enzymes also rises during clinical death from blood loss preceded by hypotension of varied duration or with different levels of the arterial pressure. Comparison of the changes observed in the specific activity of these enzymes in subcellular fractions of the gray matter indicates the existence of a general mechanism for the activation of proteolysis in nerve tissue in the terminal states investigated.

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